HKST
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Cat.code:
tlrl-hkst2
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ABOUT
Heat Killed Salmonella typhimurium
HKST is a heat killed preparation of the flagellated Gram negative bacterium, Salmonella typhimurium.
Recognition of HKST is mediated by TLR2 and TLR4 [1-2].
TLR2 and TLR4 recognize cell wall components from HKST, such as peptidoglycan (PGN) and lipopolysaccharide (LPS) resulting in the production of pro-inflammatory cytokines, such as IL-6 and TNF-α [1].
InvivoGen’s HKST is a potent agonist of TLR2 and TLR4.
References:
Lembo A. et al., 2003. Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice. Infect Immun. 71(10):6058-62.
Arpaia N. et al., 2011. TLR signaling is required for virulence of an intracellular pathogen Cell, 144(5):675-688.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
104-109 cells/ml to activate TLR2, 106-109 cells/ml to activate TLR4
Insoluble (resuspended HKST results in a cloudy suspension)
CONTENTS
Contents
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Product:HKST
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Cat code:tlrl-hkst2
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Quantity:10^10 cells
1.5 ml endotoxin-free water
HKST is provided lyophilized.
Shipping & Storage
- Shipping method: Room temperature
- Upon receipt, store at 4°C.
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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