HKEB
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Cat.code:
tlrl-hkeb2
- Documents
ABOUT
Heat Killed E. coli 0111:B4
HKEB is a heat killed preparation of the gram negative bacterium, E.coli O111:B4. Cell wall components from this bacterium, such as peptidoglycan (PGN) and lipopolysaccharide (LPS), are recognized by the toll-like receptor (TLR) 2 and TLR4 [1].
It has been demonstrated that HKEB can stimulate TLR2 and induce the production of NF-κB and pro-inflammatory cytokines, such as IL-8 [2]. HKEB is a potent stimulator of TLR2 and TLR4.
References:
1. Takeuchi O. et al., 1999. Differential roles of TLR2 and TLR4 in recognition of gram negative and gram-positive bacterial cell wall components. Immunity, 11(4):443-51.
2. van Riet E. et al., 2009. Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for TH1/TH2 polarization. BMC Immunology, 10:9.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
105-107 cells/ml
Insoluble (resuspended HKEB results in a cloudy suspension)
>1 EU/109 cells
Cellular assays
Each lot is functionally tested and validated.
CONTENTS
Contents
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Product:HKEB
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Cat code:tlrl-hkeb2
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Quantity:10^10 cells
1.5 ml sterile endotoxin-free water
Shipping & Storage
- Shipping method: Room temperature
- -20°C
Storage:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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