pFUSE-hIgG1e6-Fc1 Unit size Cat. code Docs Qty Price
20 µg
pFUSE-hIgG1e6-Fc2 Unit size Cat. code Docs Qty Price
20 µg

pFUSE-hIgG1e6-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated P257I/Q311I and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.

pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.

Datta-Mannan A. et al., 2007. Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates. Drug Metab. Dispos. 35: 86 - 94.

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Isotype: IgG1 human
Mutations: P257I/Q311I
- Increased binding to FcgRIIIA
- Unchanged half-life

Both plasmids are selectable with Zeocin™.

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• 20 μg of lyophilized DNA
• 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)

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