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Monoclonal antibody to mouse TLR2
Mouse & Human TLR2 Detection and Neutralizing antibody - Monoclonal Mouse IgG1 (T2.5)
MAb mTLR2 (T2.5) is a monoclonal antibody that reacts with mouse Toll-like receptor 2 (TLR2, CD282). MAb mTLR2 is an antagonistic antibody.
It has been tested by flow cytometric analysis of RAW264.7 cells.
The antibody is cross reactive with human TLR2.Back to the top
Clonality: Monoclonal antibody
Applications: Neutralization of mouse TLR2-induced cellular activation. This antibody can also be used for flow cytometry, immunohistology on frozen tissue sections and immunoprecipitation.
Specificity: Human & mouse TLR2
Isotype: Mouse IgG1
Formulation: 0.2 mm filtered solution in sodium phosphate buffer with glycine, saccharose and stabilizing agentsBack to the top
- 100 μg purified monoclonal anti-mTLR2 antibody (MAb-mTLR2) provided lyophilized.
Product is shipped at room temperature.
Store lyophilized MAb-mTLR2 at -20°C.
Product is stable for 1 year. Resuspended MAb-mTLR2 should be stored at -20°C for 1 year.Back to the top
Toll-Like receptors (TLRs) play a critical role in early innate immunity toinvading pathogens by sensing microorganisms. These evolutionary conserved receptors recognize highly conserved structural motifs only expressed by microbial pathogens, called pathogen-associated microbial patterns (PAMPs). Stimulation of TLRs by PAMPs initiates a signaling cascade leading to the secretion of proinflammatory cytokines following NF-κB activation. To date ten human and twelve murine TLRs have been characterized, TLR1 to TLR10 in humans, and TLR1 to TLR9, TLR11, TLR12 and TLR13 in mice, the homolog of TLR10 being a pseudogene.
TLR2 is involved in the recognition of a wide array of microbial molecules. TLR2 recognizes lipoteichoic acid and lipoprotein from gram- positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast cell wall. Moreover, TLR2 participates in the recognition of some types of LPS. TLR2 is known to heterodimerize with other TLRs, a property believed to extend the range of microbial molecules that TLR2 can recognize. TLR2 cooperates with TLR6 in response to diacylated mycoplasmal lipopeptide , and associates with TLR1 to recognize triacylated lipopetides . Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14 .
1. Girard R et al., 2003. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci. 116(Pt 2):293-302.
2. Ozinsky A. et al., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA. 97(25):13766-71.
3. Lotz S. et al., 2004. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 75(3):467-77.