Antibodies against human and murine TLR2
InvivoGen provides a collection of monoclonal antibodies targeting human and murine Toll-like receptor 2 (TLR2) for neutralization and detection.
TLR2 is involved in the recognition of a wide array of microbial molecules. TLR2 recognizes peptidoglycan, lipoteichoic acid, and lipoprotein from Gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from the yeast cell wall.
TLR2 cooperates with TLR6 in response to diacylated mycoplasmal lipopeptides [1], and associates with TLR1 to recognize triacylated lipopeptides [2,3].
Simultaneous expression of the extracellular and intracellular domains of both TLR1 and TLR2 is essential for ligand recognition and subsequent ligand-induced signal activation [4]. Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14 [5].
References
1. Girard R. et al., 2003. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci. 116:293-302.
2. Ozinsky A. et al., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. PNAS. 97:13766-71.
3. Thakran S. et al., 2008. Identification of Francisella tularensis lipoproteins that stimulate the Toll-like receptor (TLR) 2/TLR1 heterodimer. J Biol Chem 283: 3751-9.
4. Sandor F. et al., 2003. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkB signaling. J Cell Biol. 162: 1099-10.
5. Lotz S. et al., 2004. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 75(3):467-77.