|Anti-hDectin-1-IgG||Unit size||Cat. code||Docs||Qty||Price|
Human Dectin-1 Neutralizing antibody - Monoclonal Mouse IgG1
Human Dectin-1 Detection and Neutralizing antibody - Monoclonal Mouse IgG1
Anti-hDectin-1-IgG is a monoclonal mouse IgG isotype 1 antibody specific for human Dectin-1.
Anti-hDectin-1-IgG is a neutralizing antibody, it blocks hDectin-1-induced cellular activation.
Anti-hDectin-IgG can also be used for flow cytometry.Back to the top
Clonality: Monoclonal antibody
Application: Neutralization of human dectin1-induced cellular activation. It can also be used for flow cytometry.
Specificity: Human Dectin 1
Isotype: Mouse IgG1, kappa
Formulation: 0.2 µm filtered solution in PBS with 5% saccharoseBack to the top
anti-hDectin1-IgG is provided lyophilized.
- 100 μg purified monoclonal hDectin-1 IgG1 antibody (anti-hDectin1-IgG)
Product is shipped at room temperature.
Store lyophilized anti-hDectin1-IgG at -20°C.
Lyophilized anti-hDectin1-IgG is stable for 1 year at -20°C.
Resuspended anti-hDectin1-IgG is stable up to 3 months when stored at -20°C.Back to the top
Dectin-1 is a pattern-recognition receptor that plays an important role in antifungal innate immunity. Dectin-1, which is expressed on phagocytes, is a specific receptor for β-glucans .
β-glucans are glucose polymers found in cell walls of fungi, including yeast S. cerevisiae and C. albicans.
Dectin-1 binds and internalizes β-glucans and mediates the production of reactive oxygen species (ROS), activation of NF-κB and subsequent secretion of proinflammatory cytokines.
Zymosan, a cell wall preparation of S. cerevisiae composed primarily of β-glucan, mannan, mannoprotein and chitin, induces immune responses that are both Dectin-1 and TLR-2-dependent .
1. Brown GD. et al., 2003. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med. 197: 1119- 24.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll- likereceptor 2. J Exp Med. 197: 1107- 17.