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Anti-hDectin-1-IgG

Anti-hDectin-1-IgG Unit size Cat. code Docs Qty Price
Human Dectin-1 Neutralizing antibody - Monoclonal Mouse IgG1
100 µg
mabg-hdect
+-
$325.00

Human Dectin-1 Detection and Neutralizing antibody - Monoclonal Mouse IgG1

Anti-hDectin-1-IgG is a monoclonal mouse IgG isotype 1 antibody specific for human Dectin-1.

Anti-hDectin-1-IgG is a neutralizing antibody, it blocks hDectin-1-induced cellular activation.

Anti-hDectin-IgG can also be used for flow cytometry.

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Specifications

Clonality: Monoclonal antibody

Application: Neutralization of human dectin1-induced cellular activation. It can also be used for flow cytometry.

Specificity: Human Dectin 1

Isotype: Mouse IgG1

Clone: 22H8

Formulation: 0.2 µm filtered solution in PBS with 5% saccharose

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Contents

anti-hDectin1-IgG is provided lyophilized.

  • 100 μg purified monoclonal hDectin-1 IgG1 antibody (anti-hDectin1-IgG)

Product is shipped at room temperature.

Store lyophilized anti-hDectin1-IgG at -20°C.

Lyophilized anti-hDectin1-IgG is stable for 1 year at -20°C.

Resuspended anti-hDectin1-IgG is stable up to 3 months when stored at -20°C.

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Description

Dectin-1 is a pattern-recognition receptor that plays an important role in antifungal innate immunity. Dectin-1, which is expressed on phagocytes, is a specific receptor for β-glucans [1].

β-glucans are glucose polymers found in cell walls of fungi, including yeast S. cerevisiae and C. albicans.

Dectin-1 binds and internalizes β-glucans and mediates the production of reactive oxygen species (ROS), activation of NF-κB and subsequent secretion of proinflammatory cytokines.

Zymosan, a cell wall preparation of S. cerevisiae composed primarily of β-glucan, mannan, mannoprotein and chitin, induces immune responses that are both Dectin-1 and TLR-2-dependent [2].

 

1. Brown GD. et al., 2003. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med. 197: 1119- 24.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll- likereceptor 2. J Exp Med. 197: 1107- 17.

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