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Anti-hDectin-2-IgG

Anti-hDectin-2-IgG Unit size Cat. code Docs Qty Price
Human Dectin-2 Neutralizing antibody - Monoclonal mouse IgG2a
100 µg
mabg-hdect2
+-
$325.00

Human Dectin-2 Neutralizing antibody - Monoclonal mouse IgG2a

Anti-hDectin-2-IgG is a monoclonal mouse IgG2a antibody against human Dectin-2 (hDectin-2).

This antibody was screened for flow cytometry and neutralization activity.

Anti-hDectin- 2 is produced in hybridomas and purified by affinity chromatography with protein G / agarose.

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Specifications

Clonality: Monoclonal antibody

Application: Neutralizing antibody, Anti-hDectin-2-IgG blocks hDectin-2-induced cellular activation. Anti-hDectin-2-IgG can also be used for flow cytometry.

Specificity: Human Dectin 2

Isotype: Mouse IgG2a

Clone: Q7-4B5

Formulation: 0.2 µm filtered solution in 68 mM phosphate buffer with 91 mM glycine, 5% w/v saccharose and stabilizing agents

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Contents

  • 100 µg purified anti-hDectin-2-IgG, provided azide-free and lyophilized

room temperature Product is shipped at room temperature.

store Store lyophilized antibody at -20°C.

stability Product is stable for 6 months.

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Description

Dectin-2 is a member of the C-type lectin receptor (CLR) family and plays an important role in antifungal innate immunity [1].
CLRs comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. The lectin activity of these receptors is mediated by conserved carbohydrate-recognition domains (CRDs).
Dectin-2 is a type II transmembrane CLRs with a single CRD domain. Dectin-2 binds high mannose-type  carbohydrates and was shown to be the functional receptor for a-mannans. Upon binding to its ligand, Dectin-2 signals through the kinase Syk and the adaptors CARD9/Bcl-10/MALT1 triggering the activation of NF-kB and the subsequent production of pro-inflammatory cytokines [1, 2].
Dectin-2 is implicated in anti-bacterial immunity and allergy [3]. In fact, it has been demonstrated that Dectin-2 is important for the induction of Th17 in response to fungal infection [4].

 

References

1. Sancho D & Reis e Sousa C., 2012. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu Rev Immunol. 30:491-529.
2. Hernández-Santos N. & Gaffen SL., 2012. Th17 cells in immunity to Candida albicans. Cell Host Microbe. 11(5):425-35.
3. Drummond R. et al., 2011. The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol. 41:276-81.
4. Saijo S. et al., 2010. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 32(5):681-91.

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