RP105
| pUNO1-hRP105 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pUNO1 bearing the human RP105 gene |
20 µg |
puno1-hrp105 |
| pUNO1-mRP105 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pUNO1 bearing the mouse RP105 gene |
20 µg |
puno1-mrp105 |
Expression-ready ORF Clones
Alias : CD180, Ly78, Ly64
Radioprotective, 105kD.
CD180 molecule.
CD180 antigen.
Lymphocyte antigen 64 (mouse) homolog.
RP105, a TLR-related protein, was identified in B cells and acts as both an LPS sensor and a regulator of B cell proliferation [1]. B-cells lacking RP105 were shown to be severely impaired in LPS-induced proliferation and antibody production. Like TLR4, RP105 requires a MD2-related protein, MD1, for its surface expression. Furthermore, the expression of RP105 was reported to strongly increase during differentiation, suggesting that RP105 is also important in monocyte function [2].
1. Miyake K. et al., 2000. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J Endotoxin Res, 6(5):389-91
2. Zarember A. and PJ. Godowski, 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol, 168(2):554-61
Specifications
Human RP105 (pUNO1-hRP105)
Genbank : AK313177.1
ORF size : 1986 bp
Subclone : NcoI - NheI
Mouse RP105 (pUNO1-mRP105)
Genbank : D37797.1
ORF size : 1986 bp
Subclone : NcoI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.