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RP105

pUNO1-hRP105 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human RP105 gene
20 µg
puno1-hrp105
+-
$384.00
pUNO1-mRP105 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse RP105 gene
20 µg
puno1-mrp105
+-
$384.00

Expression-ready ORF Clones

Alias : CD180, Ly78, Ly64

 

Radioprotective, 105kD.
CD180 molecule.
CD180 antigen.
Lymphocyte antigen 64 (mouse) homolog.

 

RP105, a TLR-related protein, was identified in B cells and acts as both an LPS sensor and a regulator of B cell proliferation [1]. B-cells lacking RP105 were shown to be severely impaired in LPS-induced proliferation and antibody production. Like TLR4, RP105 requires a MD2-related protein, MD1, for its surface expression. Furthermore, the expression of RP105 was reported to strongly increase during differentiation, suggesting that RP105 is also important in monocyte function [2].

1. Miyake K. et al., 2000. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J Endotoxin Res, 6(5):389-91
2. Zarember A. and PJ. Godowski, 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol, 168(2):554-61

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Specifications

Human RP105 (pUNO1-hRP105)

Genbank : AK313177.1
ORF size : 1986 bp
Subclone : NcoI - NheI

Mouse RP105 (pUNO1-mRP105)

Genbank : D37797.1
ORF size : 1986 bp
Subclone : NcoI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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