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MBL2

pUNO1-hMBL2 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human MBL2 gene
20 µg
puno1-hmbl2
+-
$371.00
pUNO1-mMBL2 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse MBL2 gene
20 µg
puno1-mmbl2
+-
$371.00

Alias : COLEC1, MBL, MBP1

 

Mannose binding lectin 2
Mannose-binding lectin (protein C) 2, soluble.

 

Mannose-binding lectin (MBL), also called mannose-binding protein (MBP) is a member of the collectin family of proteins in which collagen structures are associated with carbohydrate-recognizing lectin domains [1]. MBL is a serum protein that binds a large variety of sugar moieties expressed by bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection [2]. MBL can mediate phagocytosis of microorganisms and induce inflammatory responses. MBL can also activate the complement system via MBL-associated serine proteases (MASPs). MBL is encoded by a single human gene, mbl2 (mbl1 is a pseudogene) and by two mouse genes, mbl1 and mbl2 [3].

1. Holmskov U. et al., 2003. Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol. 21:547-78..
2. Jack DL. & Turner MW., 2003. Anti-microbial activities of mannose-binding lectin. Biochem Soc Trans. 31(Pt 4):753-7.
3. Sastry, R. et al., 1995. Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes. Mamm. Genome 6: 103-110. 

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Specifications

Human MBL2 (pUNO1-hMBL2)

Genbank : AY826184.1
ORF size : 747 bp
Subclone : BspLU11I - NheI

Mouse MBL2 (pUNO1-mMBL2)

Genbank : NM_010776.1
ORF size : 735 bp
Subclone : BspLU11I - NheI

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Contents

- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

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