|pUNO1-hDCSIGN1Aa||Unit size||Cat. code||Docs||Qty||Price|
pUNO1 bearing the human DC-SIGN1A (mb) gene, type I isoform
Expression-ready ORF Clones
Alias : DCSIGN1, CD209, CD209A, CDSIGN, CLEC4L
Dendritic cell-specific ICAM-3 grabbing nonintegrin.
DC-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIGN) is a C-type lectin involved in the capture of different pathogens. DC-SIGN recognizes distinct carbohydrate structures such as the viral envelope glycoproteins expressed by the HIV1 , hepatitis C virus, and Ebola virus. Non-viral pathogens can also interact with DC-SIGN including yeast, parasites and bacteria, such as Mycobacteria tuberculosis . Following recognition, DC-SIGN internalizes the pathogens for processing and antigen presentation. The central feature of the pathogens recognized by DC-SIGN is that they misuse DC-SIGN by distinct mechanisms that either circumvent antigen processing or alter TLR-mediated signaling, skewing T-cell responses .
1. Kwon DS. et al., 2002. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity. 16(1):135-44.
2. Appelmelk BJ. et al., 2003. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol. 170(4):1635-9.
3. Van Kooyk Y. & Geijtenbeek TB. 2003. DC-SIGN: escape mechanism for pathogens. Nat Rev Immunol. 3(9):697-709.
Human DC-SIGN1A (mb) type I isoform (pUNO1-hDCSIGN1Aa)
ORF size : NM_021155.3 with one silent variation in codon Arg221
ORF size : 1215 bp
Subclone : BspHI - NheI
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.Back to the top