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pBOOST3 mTBK1

pBOOST3-mTBK1 Unit size Cat. code Docs Qty Price
TBK1
20 µg
pbst3-mtbk1
+-
$433.00

Enhancement of DNA vaccine immunogenicity

pBOOST3-mTBK1 plasmid expresses the mouse TANK-binding kinase 1 (TBK1) gene. TBK1, a non-canonical IkB kinase, was recently shown to mediate the adjuvant effect of DNA vaccines [1]. Administration of DNA vaccines induces the production of type I interferons and inflammatory cytokines in a CpG-independent manner but in a TBK1-dependent manner. Therefore, co-administration of a TBK1-expressing plasmid is expected to further boost DNA vaccine-induced immunogenicity.

pBOOST3-mTBK1 contains the EF-1α/HTLV composite promoter coupled to the SV40 enhancer and is selectable in E. coli with Zeocin™.

1. Ishii KJ. et al., 2008. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451: 725-729

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Specifications

Gene: TBK1
Species:
Murine
Backbone:
 pBOOST3
Selection: Zeocin

Enhancement of DNA vaccine immunogenicity

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Contents

- 20 µg of lyophilized DNA
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)

Product is shipped at room temperature. Store at -20°C. Plasmids are stable up to one year when properly stored.

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Details

pBOOST3 map

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