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Enhancement of DNA vaccine immunogenicity
pBOOST3-mTBK1 plasmid expresses the mouse TANK-binding kinase 1 (TBK1) gene. TBK1, a non-canonical IkB kinase, was recently shown to mediate the adjuvant effect of DNA vaccines .
Administration of DNA vaccines induces the production of type I interferons and inflammatory cytokines in a CpG-independent manner but in a TBK1-dependent manner.
Therefore, co-administration of a TBK1-expressing plasmid is expected to further boost DNA vaccine-induced immunogenicity.
pBOOST3-mTBK1 contains the EF-1α/HTLV composite promoter coupled to the SV40 enhancer and is selectable in E. coli with Zeocin™.
1. Ishii KJ. et al., 2008. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451: 725-729.Back to the top
Enhancement of DNA vaccine immunogenicityBack to the top
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperatureBack to the top
Back to the top