|pBOOST2-wthIRF1||Unit size||Cat. code||Docs||Qty||Price|
pBOOST2 Human Wild-type IRF-1
|pBOOST2-wtmIRF1||Unit size||Cat. code||Docs||Qty||Price|
pBOOST2 Murine Wild-type IRF-1
Genetic adjuvants for DNA vaccines with wild-type IRF1 genes | Increase Th2 response
pBOOST2-wtIRF1 plasmids express the human or murine wild-type interferon regulatory factor 1 (IRF-1) gene. IRF-1 has been described to primarily increase Th2 antibody responses .
Following intramuscular or gene gun injections of DNA vaccines, IRF-1 can increase the titers of antibodies up to 10-fold.
pBOOST2-wtIRF1 plasmids express the transgene under the control of the strong and ubiquitous EF-1α/HTLV composite promoter and are selectable in E. coli with Zeocin™.
1. Sasaki S. et al., 2002. Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors. J Virol.76(13):6652-9.Back to the top
Gene: wild-type IRF-1 gene
Species: Human or Murine
Th2 polarizationBack to the top
- 20 µg of lyophilized DNA
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)
Product is shipped at room temperature.
Store at -20°C.
Plasmids are stable up to one year when properly stored.Back to the top
Back to the top