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pBOOST2 wtIRF1

pBOOST2-wthIRF1 Unit size Cat. code Docs Qty Price
pBOOST2 Human Wild-type IRF-1
20 µg
pbst2-wthirf1
+-
$448.00
pBOOST2-wtmIRF1 Unit size Cat. code Docs Qty Price
pBOOST2 Murine Wild-type IRF-1
20 µg
pbst2-wtmirf1
+-
$448.00

Genetic adjuvants for DNA vaccines with wild-type IRF1 genes | Increase Th2 response

pBOOST2-wtIRF1 plasmids express the human or murine wild-type interferon regulatory factor 1 (IRF-1) gene. IRF-1 has been described to primarily increase Th2 antibody responses [1].

Following intramuscular or gene gun injections of DNA vaccines, IRF-1 can increase the titers of antibodies up to 10-fold.

pBOOST2-wtIRF1 plasmids express the transgene under the control of the strong and ubiquitous EF-1α/HTLV composite promoter and are selectable in E. coli with Zeocin™.

 

Reference:

1. Sasaki S. et al., 2002. Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors. J Virol.76(13):6652-9.

Figures


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Specifications

Gene: wild-type IRF-1 gene

Species: Human or Murine

Backbone: pBOOST2

Selection: Zeocin

Th2 polarization

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Contents

  • 20 µg of lyophilized DNA
  • 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)

room temperature Product is shipped at room temperature.

store Store at -20°C.

stability Plasmids are stable up to one year when properly stored.

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Details

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