CDS & STING Inhibitors

InvivoGen provides inhibitors of the cytosolic dsDNA Sensor (CDS) and STING signaling pathways which are involved in the detection of cytosolic nucleic acids. These inhibitors include:

  • BX795: inhibits the catalytic activity of TBK1/IKKε
  • H-151: is a potent, irreversible and selective inhibitor of STING
  • RU.521: is described as a small molecule inhibitor of cGAS

These inhibitors are chemically synthesized and are characterized by UHPLC, NMR and MS.

For each lot, the biological activity is validated and the absence of bacterial contamination (e.g. endotoxins) is verified using cell-based assays.

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