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RIPK3

pUNO1-hRIPK3 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human RIPK3 gene
20 µg
puno1-hripk3
+-
$384.00
pUNO1-mRIPK3a Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse RIPK3 gene, isoform 1
20 µg
puno1-mripk3
+-
$384.00

Expression-ready ORF Clones

Alias : RIP3

 

Receptor interacting serine/threonine kinase 3.

 

Receptor-interacting protein 3 (RIP3) is a member of the RIP Ser/Thr kinase family [1]. Unlike RIP1 and RIP2, RIP3 possesses neither a death domain nor a CARD motif at its unique C terminus [2]. RIP3 is a potent inducer of apoptosis, an activity readily localizable to its C terminus. RIP3 binds RIP within the TNFR-1 signaling complex and attenuates its ability to engage the NF-kB pathway [2,3]. Upon TNF stimulation, RIP1 is recruited to the TNFR1 signaling complex to activate NF-kB. RIP3 is then recruited and phosphorylates RIP1 inhibiting its ability to activate NF-kB. Thus RIP3 acts as a modulator that can limit persistent activation of the NF-kB pathway [3].

1. Yu PW. et al., 1999. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. Curr Biol. 9(10):539-42.
2. Sun X. et al., 1999. RIP3, a novel apoptosis-inducing kinase. J Biol Chem. 274(24):16871-5.
3.Sun X. et al., 2002. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J Biol Chem. 277(11):9505-11. 

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Specifications

Human RIPK3 (pUNO1-hRIPK3)

Genbank : NM_006871.3
ORF size : 1557 bp
Subclone : BspLU11I - NheI

Mouse RIPK3 isoform 1 (pUNO1-mRIPK3a)

Genbank : NM_019955.2 with silent variation in codon Val291.
ORF size : 1461 bp
Subclone : AgeI - EcoRI

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Contents

- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

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