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RIG-I (DDX58)

pUNO1-mRIGI Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse RIG-I gene
20 µg
puno1-mrigi
+-
$371.00
pUNO1-hRIGI Unit size Cat. code Docs Qty Price
pUNO1 bearing the human RIG-I gene
20 µg
puno1-hrigi
+-
$371.00
pUNO1-hRIGI-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing a dominant negative version of the human RIG-I gene
20 µg
puno1-hrigi-dn
+-
$392.00

Alias : DDX58

 

RNA helicase retinoic acid inducible gene I
DEAD [Asp-Glu-Ala-Asp] box polypeptide 58

 

Available versions:

  • Wild type RIG-I
  • Dominant negative RIG-I (see the "Details" tab)
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Specifications

Mouse RIG-I (pUNO1-mRIGI)

Genbank : BC152540.1
ORF size : 2781 bp
Subclone : BspHI - XbaI

Human RIG-I (pUNO1-hRIGI)

Genbank : NM_014314.3
ORF size : 2778 bp
Subclone : AgeI - NheI

Human RIG-I-DN (pUNO1-hRIGI-DN)

ORF size : 2130 bp
Subclone : AgeI - NheI

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Contents

- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

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Details

RIG-I DN (also called RIG-IC)

Dominant negative RIG-I (RIG-IC) was generated by removing the two caspase recruitment domains (CARD) found at the N terminus (aa1-217). Expression of RIG-IC in L929 cells was shown to inhibit virus-induced gene expression [1].

1. Yoneyama M. et al., 2005. Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity. J. Immunol. 175:2851-58.

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Citations

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