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IRAK3

Product Unit size Cat. code Docs. Qty. Price

pUNO1-hIRAK3a

pUNO1 bearing the human IRAK3 (IRAKM) gene, isoform 1

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20 µg

puno1-hirak3
+-
$473

pUNO1-mIRAK3

pUNO1 bearing the mouse IRAK3 (IRAKM) gene

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20 µg

puno1-mirak3
+-
$473
  • About
  • Specifications
  • pUNO1 Contents

Expression-ready ORF Clones

Alias : IRAKM, IRAK-M

 

Interleukin-1 receptor-associated kinase 3.
IL-1R associated kinase M.

 

Interleukin-1 receptor-associated kinase (IRAK)-M is an inactive kinase found mainly in cells of the monocytic lineage [1], whereas other IRAKs are ubiquitous. IRAK-M negatively regulates TLR signaling. TLR stimulation induces IRAK-M which in turn down-regulates TLR signaling by preventing the dissociation of IRAK-1 and IRAK-4 from MyD88 and the formation of IRAK-1/TRAF6 complexes [2]. IRAK-M-deficient cells exhibit increased cytokine production upon LPS stimulation and reduced endotoxin tolerance. IRAK-M is also involved in peptidoglycan-induced tolerance [3].

1. Wesche H. et al., 1999. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem, 274(27):19403-10.
2. Kobayashi K. et al., 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 110(2): 191-202.
3. Nakayama K. et al., 2004. Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem. 279(8):6629-34. 

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Specifications

Human IRAK3 isoform 1 (pUNO1-hIRAK3a)

Genbank : AF113136
ORF size : 1791 bp
Subclone : AgeI - NheI

Mouse IRAK3 (pUNO1-mIRAK3)

Genbank : NM_028679.3
ORF size : 1830 bp
Subclone : NcoI - NheI

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pUNO1 Contents

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

stability Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Alert Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.

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