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IRAKM (IRAK3)

pUNO1-hIRAKMa Unit size Cat. code Docs Qty Price
pUNO1 bearing the human IRAKM gene, isoform 1
20 µg
puno1-hirakm
+-
$384.00
pUNO1-mIRAKM Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse IRAKM gene
20 µg
puno1-mirakm
+-
$384.00

Expression-ready ORF Clones

Alias : IRAK3, IRAK-M

 

Interleukin-1 receptor-associated kinase 3.
IL-1R associated kinase M.

 

Interleukin-1 receptor-associated kinase (IRAK)-M is an inactive kinase found mainly in cells of the monocytic lineage [1], whereas other IRAKs are ubiquitous. IRAK-M negatively regulates TLR signaling. TLR stimulation induces IRAK-M which in turn down-regulates TLR signaling by preventing the dissociation of IRAK-1 and IRAK-4 from MyD88 and the formation of IRAK-1/TRAF6 complexes [2]. IRAK-M-deficient cells exhibit increased cytokine production upon LPS stimulation and reduced endotoxin tolerance. IRAK-M is also involved in peptidoglycan-induced tolerance [3].

1. Wesche H. et al., 1999. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem, 274(27):19403-10.
2. Kobayashi K. et al., 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 110(2): 191-202.
3. Nakayama K. et al., 2004. Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem. 279(8):6629-34. 

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Specifications

Human IRAKM isoform 1 (pUNO1-hIRAKMa)

Genbank : AF113136
ORF size : 1791 bp
Subclone : AgeI - NheI

Mouse IRAKM (pUNO1-mIRAKM)

Genbank : NM_028679.3
ORF size : 1830 bp
Subclone : NcoI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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