|pUNO1-hIRAKMa||Unit size||Cat. code||Docs||Qty||Price|
pUNO1 bearing the human IRAKM gene, isoform 1
|pUNO1-mIRAKM||Unit size||Cat. code||Docs||Qty||Price|
pUNO1 bearing the mouse IRAKM gene
Expression-ready ORF Clones
Alias : IRAK3, IRAK-M
Interleukin-1 receptor-associated kinase 3.
IL-1R associated kinase M.
Interleukin-1 receptor-associated kinase (IRAK)-M is an inactive kinase found mainly in cells of the monocytic lineage , whereas other IRAKs are ubiquitous. IRAK-M negatively regulates TLR signaling. TLR stimulation induces IRAK-M which in turn down-regulates TLR signaling by preventing the dissociation of IRAK-1 and IRAK-4 from MyD88 and the formation of IRAK-1/TRAF6 complexes . IRAK-M-deficient cells exhibit increased cytokine production upon LPS stimulation and reduced endotoxin tolerance. IRAK-M is also involved in peptidoglycan-induced tolerance .
1. Wesche H. et al., 1999. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem, 274(27):19403-10.
2. Kobayashi K. et al., 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 110(2): 191-202.
3. Nakayama K. et al., 2004. Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem. 279(8):6629-34.
Human IRAKM isoform 1 (pUNO1-hIRAKMa)
Genbank : AF113136
ORF size : 1791 bp
Subclone : AgeI - NheI
Mouse IRAKM (pUNO1-mIRAKM)
Genbank : NM_028679.3
ORF size : 1830 bp
Subclone : NcoI - NheI
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.Back to the top