MD1
| pUNO1-hMD1 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pUNO1 bearing the human MD1 gene |
20 µg |
puno1-hmd1 |
| pUNO1-mMD1 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pUNO1 bearing the mouse MD1 gene |
20 µg |
puno1-mmd1 |
Expression-ready ORF Clones
Alias : Ly86
Lymphocyte antigen 86.
Myeloid differentiation factor 1.
MD-1 was identified by immunoprecipitation as a molecule that physically associates with RP105. Stable expression of MD-1 was shown to induce an increase in cell surface RP105 on a cell line that expresses RP105 alone, suggesting that MD-1 is important for efficient cell surface expression of RP105 [1]. Similarly to the TLR4/MD2 complex, the RP105/MD1 complex is involved in LPS response leading to LPS-induced B-cell proliferation, antibody production, and B7.2/CD86 up-regulation [2]. MD-1 plays also a role in the regulation of allogeneic and xenogeneic skin graft survival[3].
1. Miyake K. et al., 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol, 161(3):1348-53.
2. Nagai Y. et al., 2002. Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood, 99(5):1699-705.
3. Hadidi S. & Gorczynski RM., 2004. MD-1 expression regulates direct and indirect allorecognition. Tissue Antigens. 63(2):132-41.
Specifications
Human MD1 (pUNO1-hMD1)
Genbank : NM_004271.3
ORF size : 489 bp
Subclone : BspHI - NheI
Mouse MD1 (pUNO1-mMD1)
Genbank : NM_010745.2
ORF size : 489 bp
Subclone : BspHI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.