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MD1

pUNO1-hMD1 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human MD1 gene
20 µg
puno1-hmd1
+-
$384.00
pUNO1-mMD1 Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse MD1 gene
20 µg
puno1-mmd1
+-
$384.00

Expression-ready ORF Clones

Alias : Ly86

 

Lymphocyte antigen 86.
Myeloid differentiation factor 1.

 

MD-1 was identified by immunoprecipitation as a molecule that physically associates with RP105. Stable expression of MD-1 was shown to induce an increase in cell surface RP105 on a cell line that expresses RP105 alone, suggesting that MD-1 is important for efficient cell surface expression of RP105 [1]. Similarly to the TLR4/MD2 complex, the RP105/MD1 complex is involved in LPS response leading to LPS-induced B-cell proliferation, antibody production, and B7.2/CD86 up-regulation [2]. MD-1 plays also a role in the regulation of allogeneic and xenogeneic skin graft survival[3].

 

1. Miyake K. et al., 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol, 161(3):1348-53.
2. Nagai Y. et al., 2002. Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood, 99(5):1699-705.
3. Hadidi S. & Gorczynski RM., 2004. MD-1 expression regulates direct and indirect allorecognition. Tissue Antigens. 63(2):132-41.

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Specifications

Human MD1 (pUNO1-hMD1)

Genbank : NM_004271.3
ORF size : 489 bp
Subclone : BspHI - NheI

Mouse MD1 (pUNO1-mMD1)

Genbank : NM_010745.2
ORF size : 489 bp
Subclone : BspHI - NheI

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Contents

- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

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