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LBP

pUNO1-hLBP Unit size Cat. code Docs Qty Price
pUNO1 bearing the human LBP gene
20 µg
puno1-hlbp
+-
$384.00
pUNO1-mLBP Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse LBP gene
20 µg
puno1-mlbp
+-
$384.00

Expression-ready ORF Clones

Alias : BPIFD2

 

Lipopolysaccharide-binding protein (LBP) is a serum glycoprotein synthesized in the liver [1]. LBP binds to a variety of lipopolysaccharides (LPS) and to lipid A, the lipid moiety of LPS. LPS bound to LBP is a ligand for CD14 which in turn presents LPS to TLR4 by transferring LPS to MD2. LBP plays a dual role, both potentiating and decreasing cell responses to LPS [2]. Low concentrations of LBP enhance cell stimulation, whereas high LBP concentrations inhibit cell responses to LPS. LBP attenuates signal responses by interfering with LPS transfer from CD14 to the TLR4/MD2 receptor complex [3].

 

1. Schumann RR. et al., 1990. Structure and function of lipopolysaccharide binding protein. Science. 249(4975):1429-31.
2. Gutsmann T. et al., 2001. Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells. Infect Immun. 69(11):6942-50.
3. Thompson PA. et al., 2003. Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS. J Biol Chem. 278(31):28367-71.

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Specifications

Human LBP (pUNO1-hLBP)

ORF size : 1446 bp
Subclone : NcoI - NheI

Mouse LBP (pUNO1-mLBP)

ORF size : 1446 bp
Subclone : BspHI - NheI

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Contents

- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

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