Plasmocure™
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Cat.code:
ant-pc
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ABOUT
Alternative mycoplasma removal reagent for cell cultures
Plasmocure™ is a second-line anti-mycoplasma reagent. It is recommended for the elimination of mycoplasma that appear to be Plasmocin™ -resistant [1].
Plasmocure™ combines two antibiotics that act through different mechanisms than those found in Plasmocin™:
– the first antibiotic binds to the 50S subunit of the ribosome and blocks peptidyltransferase activity
– the second antibiotic binds to isoleucyl-tRNA synthetase and halts isoleucine incorporation into mycoplasma proteins.
A two-week treatment with Plasmocure™ is usually sufficient to completely eliminate mycoplasma. If mycoplasma elimination is not completed after two weeks, Plasmocure™ can be administered for an additional week. A moderate slowdown of cell growth may be observed, but full recovery of the cell line is expected once mycoplasma are eliminated.
One 1 ml vial is sufficient to treat 1 to 3.3 liters of culture.
References:
1. Molla Kazemiha V. et al. 2019. Effectiveness of Plasmocure™ in Elimination of Mycoplasma Species from Contaminated Cell Cultures: A Comparative Study versus Other Antibiotics. Cell J. 21(2): 143-149.
All InvivoGen products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
100 mg/ml
Elimination of mycoplasma contamination
50 μg/ml
< 0.5 EU/mg
Mycoplasma and Acholesplasma (including M. orale, M. hyorhinis, M. arginini, M. fermentans, M. hominis, and A. laidlawii)
Each lot is functionally tested and validated using microbial reference strains. Absence of toxicity is validated on mammalian control cells.
CONTENTS
Contents
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Product:Plasmocure™
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Cat code:ant-pc
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Quantity:100 mg (1 ml)
Shipping & Storage
- Shipping method: Room temperature
- 4°C for 12 months
- -20°C for long-term storage
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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