Plasmocure™
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Cat.code:
ant-pc
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ABOUT
Alternative mycoplasma removal reagent for cell cultures
Plasmocure™ is a second-line anti-mycoplasma reagent. It is recommended for the elimination of mycoplasma that appear to be Plasmocin™ -resistant [1].
Plasmocure™ combines two antibiotics that act through different mechanisms than those found in Plasmocin™:
– the first antibiotic binds to the 50S subunit of the ribosome and blocks peptidyltransferase activity
– the second antibiotic binds to isoleucyl-tRNA synthetase and halts isoleucine incorporation into mycoplasma proteins.
A two-week treatment with Plasmocure™ is usually sufficient to completely eliminate mycoplasma. If mycoplasma elimination is not completed after two weeks, Plasmocure™ can be administered for an additional week. A moderate slowdown of cell growth may be observed, but full recovery of the cell line is expected once mycoplasma are eliminated.
One 1 ml vial is sufficient to treat 1 to 3.3 liters of culture.
References:
1. Molla Kazemiha V. et al. 2019. Effectiveness of Plasmocure™ in Elimination of Mycoplasma Species from Contaminated Cell Cultures: A Comparative Study versus Other Antibiotics. Cell J. 21(2): 143-149.
All InvivoGen products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
100 mg/ml
Elimination of mycoplasma contamination
50 μg/ml
< 0.5 EU/mg
Each lot is functionally tested and validated using microbial reference strains. Absence of toxicity is validated on mammalian control cells.
CONTENTS
Contents
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Product:Plasmocure™
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Cat code:ant-pc
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Quantity:100 mg (1 ml)
Shipping & Storage
- Shipping method: Room temperature
- 4°C for 12 months
- -20°C for long-term storage
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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