HepG2 hepatoma cell lines
The HepG2 cell line is a human hepatoma commonly used to study the cellular responses upon infection with hepatotropic pathogens or upon activation of the aryl hydrocarbon receptor (AhR) pathways by environmental pollutants or diet-derived compounds.
InvivoGen provides HepG2 cell lines engineered to express the secreted embryonic alkaline phosphatase (SEAP) and Lucia luciferase reporter proteins for assessing the induction of the NF-κB, the interferon regulatory factor (IRF), or the AhR signaling pathways.
- HepG2-Dual™ cells are designed to allow the simultaneous study of the NF-κB and IRF pathways by measuring the activity of SEAP and Lucia luciferase, respectively.
- HepG2-Lucia™ AhR cells are designed for the study of the AhR genomic signaling pathway by monitoring the Lucia luciferase activity.