Anti-hCD20-mIgG1
| Anti-hCD20-mIgG1 | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
Human CD20 (rituximab) antibody - Murine IgG1 |
100 µg |
hcd20-mab9 |
Monoclonal mouse IgG1 antibody against human CD20
Anti-hCD20-mIgG1 features the constant region of the mouse IgG1 isotype and the variable region of rituximab.
Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes.
Binding of rituximab to CD20 results in cell destruction through different mechanisms including direct signaling of apoptosis, complement activation and cell-mediated cytotoxicity.
Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukaemia.
Anti-hCD20-mIgG1 was generated by recombinant DNA technology. It has been produced in Chinesehamster ovary (CHO) cells and purified by affinity chromatography with protein G.
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Specifications
Clonality: Monoclonal antibody
Specificity: Targets cells expressing human CD20
Source: CHO cells
Isotype: Mouse IgG1, kappa
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Contents
- 100 µg purified anti-hCD20-mIgG1 antibody, provided azide-free and lyophilized.
Product is shipped at room temperature.
Store lyophilized antibody at -20°C.
Lyophilized product is stable for 1 year.