Ramos B lymphocytes

Ramos-Blue™ cells derive from a human Burkitt’s lymphoma which is negative for Epstein Barr virus. They have the characteristics of B lymphocytes and are routinely used as a model of B lymphocytes and for apoptosis studies.

Ramos-Blue™ cells stably express an NF-κB/AP-1-inducible SEAP (secreted embryonic alkaline phosphate) reporter construct.

Ramos-Blue™ cells express several pattern recognition receptors, including TLR3, TLR7 and TLR9. The Ramos-Blue™ cell line was isolated for its ability to respond to CpG ODNs (TLR9 ligands).

Two cell lines are available:

  • Ramos-Blue™ cells can be used to study the NF-κB and AP-1 signaling pathways in B lymphocytes, and in particular the TLR3, TLR7, TLR9 and NOD1 signaling pathways.
  • Ramos-Blue™-KD-MyD are MyD88-deficient cells. These cells do not respond or respond weakly to the activation of receptors which signaling is dependent on MyD88, such as TLR7 and TLR9. However, they are still responsive to TLR3 which is MyD88-independent.
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