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Anti-hCD20-mIgG2a

Anti-hCD20-mIgG2a Unit size Cat. code Docs Qty Price
Human CD20 (rituximab) antibody - Murine IgG2a
100 µg
hcd20-mab10
+-
$348.00

Monoclonal mouse IgG2a antibody against human CD20

Effector functions of mAb isotypes targeting CD20

Anti-hCD20-mIgG2a features the constant region of the mouse IgG2a isotype and the variable region of rituximab.

Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes.

Binding of rituximab to CD20 results in cell destruction through different mechanisms including direct signaling of apoptosis, complement activation and cell-mediated cytotoxicity.

Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukaemia.

Anti-hCD20-mIgG2a was generated by recombinant DNA technology. It has been produced in Chinese hamster ovariy (CHO) cells and purified by affinity chromatography with protein G.

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Specifications

Clonality: Monoclonal antibody

Specificity: Targets cells expressing human CD20

Source: CHO cells

Isotype: Mouse IgG2a, kappa

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Contents

  • 100 µg purified anti-hCD20-mIgG2a antibody, provided azide-free and lyophilized.

room temperature Product is shipped at room temperature.

store Store lyophilized antibody at -20°C.

stability Lyophilized product is stable for 1 year.

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Citations

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