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IL-4 & IL-13 responsive STAT6-SEAP reporter assay

Signaling pathway in HEK-Blue™ IL-4/IL-13 cells

Companion products

• Recombinant human IL-4
• Recombinant human IL-13
• Anti-hIL4R (Dupilumab)

HEK-Blue™ IL-4/IL-13 cells are designed to monitor human IL-13-induced STAT6 stimulation or inhibition. This colorimetric bioassay can be used for screening activatory molecules, such as engineered cytokines, or inhibitory molecules, such as neutralizing antibodies.

HEK-Blue™ IL-4/IL-13 cells respond specifically to recombinant human IL-4 and recombinant human IL-13. The reliable and consistent performance of HEK-Blue™ IL-4/IL-13 cells makes them suitable for release assays of therapeutic molecules that inhibit IL-4 or IL-13 signaling, such as Dupilumab, a therapeutic monoclonal antibody targeting the common IL-4Rα subunit of the IL-4 and IL-13 receptors (see figures).

Key features

Readily assessable STAT6-SEAP reporter activity
Convenient readout using QUANTI-Blue™ Solution
High sensitivity to human (h) IL-4 and hIL-13
Stability guaranteed for 20 passages

Applications

Therapeutic development
Drug screening
Release assay

IL-4 and IL-13 are cytokines that play an important role in the regulation of inflammation and immune responses.

More details

All InvivoGen products are for internal research use only and not for human or veterinary use.

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