InvivoGen’s Reviews

Innate Immunity

TLR3: racing for vaccine advantages

Toll-like receptors (TLRs) play a pivotal role in the initiation of prompt innate immune defenses, as well as in the activation of adaptive immune cells for enhanced and memory responses. Thus, TLR agonists are attractive candidates for vaccine adjuvants and cancer therapeutics

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Previous reviews


Spotlight on COVID-19: Protective immunity & Re-infection

As our understanding of COVID-19 continuously progresses, some essential questions remain open including "Does protective immunity develop after SARS-CoV-2 infection?" and "How long does it last?" There is growing evidence that re-infection by SARS-CoV-2 can occur, indicating that immunity is either not strong enough, or not long-lasting in all individuals. Therefore, it is crucial to...


Spotlight on COVID-19: Vaccine development

Globally, the vaccine development effort in response to the COVID-19 pandemic is unprecedented in terms of both scale and speed. Importantly, SARS-CoV-2 vaccines will be essential in reducing morbidity and mortality if the virus establishes itself in the population. The race is now on for the development of both a safe and, effective vaccine against SARS-CoV-2.


Spotlight on COVID-19: Predicted immune responses

Currently, there is very limited knowledge of the host immune response to SARS-CoV-2. However, SARS-Cov-2 shares sequence identity with SARS-CoV and MERS-CoV,  similar cell entry mechanisms, and the propensity to induce hyper inflammation in severe cases. Therefore, based on the accumulated clinical and experimental data on these previous viruses, predictions can be made on how the host...


Spotlight on COVID-19: Treatment with repurposed drugs

There are currently no effective drugs targeting SARS-CoV-2, the causative agent of COVID-19. The first strategy for the treatment of COVID-19 is the repurposing of existing drugs that are known to be safe in humans. Therapeutic targets against SARS-CoV-2  exist at various stages of the infection including viral attachment, entry, and replication, as well as the host cytokine response.


Spotlight on COVID-19: Infection

Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly around the world, causing a pandemic that threatens global public health. The causative agent of COVID-19 is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel β-coronavirus. Globally, the number of positive COVID-19 cases grows exponentially every day and now the race is on to find both an...

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