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STING & cGAS

A rising star in innate immunity research and immunotherapy is stimulator of interferon genes (STING), whose activation by small nucleic acids called cyclic dinucleotides (CDNs) induces Type I interferons and pro-inflammatory cytokines. STING ligands include microbial CDNs released during infection and the endogenous CDN 2’3’-cGAMP, which is produced by the sensor cGAS in response to cytosolic DNA. Many questions remain on STING’s functions, its interplay with other nucleic acid sensors and adaptors, and its role in areas such as infectious diseases, cancer and autoimmunity.
InvivoGen offers a broad selection of products to help you explore STING, its signaling partners, its cytokine induction activity and its therapeutic potential.

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