Anti-hTNF-α isotype family
The Anti-hTNF-α isotype collection features the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine TNF-α. Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases.
Adalimumab has been approved by the FDA for the treatment of various inflammatory diseases, such as rheumatoid arthritis and Crohn’s disease.
The anti-hTNF-α isotype collections has been generated by recombinant DNA technology. It has been produced in CHO cells and purified by different types of affinity chromatography: protein G for IgG isotypes, protein L for IgE and IgM, and peptide M for the human IgA isotypes.