c-di-GMP Fluorinated

STING Ligand

c-di-GMP Fluorinated (c-di[2’FdGMP]) is a synthetic analog of cyclic diguanylate monophosphate (c-di-GMP) with a fluorine atom at 2’ position of the nucleoside. c-di-GMP is a bacterial second messenger that acts a potent immunostimulant in mammals. It induces production of type I interferons (IFNs) by directly binding to the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes) [1].

The incorporation of fluorine into biologically active molecules is commonly used in medicinal chemistry to improve their metabolic stability or to modulate physicochemical properties such as lipophilicity [2, 3]. Moreover, the introduction of a fluorine atom can change the biological activities of a molecule. Interestingly, when used at low concentrations in various cellular assays, c-di-GMP Fluorinated induces higher levels of type I IFNs than does c-di-GMP.

Figures for this product

IRF INDUCTION (Lucia luciferase reporter)NF-kB INDUCTION (SEAP reporter)


Description: STING agonist
Synonym: 2’Fluoro-c-di-GMP sodium salt, 2',2''-di-F-c-didGMP, c-di(2’FdGMP)
CAS number: 1334145-18-4
Formula: C20H20F2N10O12P2 .2Na
Molecular weight: 738.36
Purity: ≥ 95% by LC/MS
Solubility: 50 mg/ml in water

Quality control:
- The biological activity is assessed by measuring induction of the interferon pathway in THP1-Blue™ ISG cells.
- The absence of endotoxins and other bacterial contaminants has been confirmed using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.


- 100 μg lyophilized c-di-GMP Fluorinated
- 1.5 ml endotoxin-free water

Product is shipped at room temperature and should be stored at -20 °C. Product is sterile filtered prior to lyophilization.


Structure of c-di-GMP Fluorinated


1. Burdette DL. et al., 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 478(7370):515-8.
2. Liu P. et al., 2008. Fluorinated Nucleosides: Synthesis and biological implication. J Fluor Chem. 129(9): 743–766.
3. Böhm HJ. et al., 2004.Fluorine in medicinal chemistry. Chembiochem. 5(5):637-43.


c-di-GMP Fluorinated

Description STING ligand
Cat. Codetlrl-nacdgf
Unit Size100 µg
Price For price or distributor address,
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