Murine STING ligand

DMXAA (also known as Vadimezan or ASA404) was initially identified as a potent tumor vascular disrupting agent in mice.
The antitumor activity of DMXAA has been linked to its ability to induce a variety of cytokines and chemokines, including TNF-α, IP-10, IL-6 and RANTES [1].

DMXAA is also a potent inducer of IFN-β [1, 2]. Despite significant preclinical promise, DMXAA failed human clinical trials. Recent studies have demonstrated that DMXAA targets the STING pathway [3], and this in a mouse-specific manner; DMXAA has no effect on human STING [4,5]. A unique point mutation (S162A) located within the cyclic-dinucleotide-binding site of human STING has been identified that renders it sensitive to DMXAA.


Description: Mouse STING ligand
Synonym: 5,6-dimethylxanthenone-4-acetic acid
CAS Number: 117570-53-3
Formula: C17H14O4
Molecular weight: 282.29
Purity: ≥ 95% by LC/MS
Solubility: 10 mg/ml in DMSO

Quality control:
- Biological activity is assessed by measuring induction of the interferon pathway in B16-Blue™ ISG cells.
- The absence of endotoxins and other bacterial contaminants is controlled using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.


- 5 mg of DMXAA

DMXAA is shipped at room temperature and should be stored at -20°C. Product is sterile filtered prior to lyophilization.


1. Jassar AS. et al., 2005. Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma. Cancer Res. 65(24):11752-61.
2. Roberts ZJ. et al., 2007. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med. 204(7):1559-69.
3. Prantner D. et al., 2012. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential. J Biol Chem. 287(47):39776-88.
4. Conlon J. et al., 2013. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol. 190(10):5216-25.
5. Kim S. et al., 2013. Anticancer Flavonoids Are Mouse-Selective STING Agonists. ACS Chem Biol. 8(7): 1396-1401.


Recent articles using InvivoGen DMXAA



Description Murine STING ligand - Xanthenone Analog
Cat. Codetlrl-dmx
Unit Size5 mg
Price For price or distributor address,
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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