CDS Ligand

VACV-70 is a 70 bp oligonucleotides containing viral DNA motifs [1]. VACV-70 derives from the vaccinia virus DNA. Transfected VACV-70 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner. VACV-70 oligonucleotide is recognized by IFI16 [1].
VACV-70 is also available complexed with the cationic lipid  transfection reagent LyoVec™ to facilitate its uptake.

VACV-70c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not IFN-inducer [1].


Activity: CDS agonist

Formulation: naked or complexed with the transfection reagent LyoVec™

Control: VACV-70c single-stranded oligonucleotide


VACV-70 Naked:
- 200 µg lyophilized VACV-70 Naked
- 1.5 ml endotoxin-free water

- 100 µg lyophilized VACV-70/LyoVec
Note: Each vial contains 25 μg of VACV-70 complexed with 50 μg LyoVec™.
- 10 ml endotoxin-free water

Product is shipped at room temperature and should be stored at -20°C.


1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.


Recent articles using InvivoGen VACV-70


VACV-70 Naked

Description CDS Agonist
Cat. Codetlrl-vav70n
Unit Size200 µg
Price For price or distributor address,
please select your country


Description CDS Agonist - LyoVec™ complexed
Cat. Codetlrl-vav70c
Unit Size100 µg
Price For price or distributor address,
please select your country
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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