CDS Agonist

HSV-60 is a 60 bp oligonucleotide containing viral DNA motifs [1]. HSV-60 derives from the herpes simplex virus 1 genome. Transfected HSV-60 was shown to potently induce IFN-β in a TLR-, DAI- and RNA Pol III-independent, but STING-, TBK1- and IRF3-dependent manner.HSV-60 is recognized by IFI16 [1].
HSV-60 is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.

HSV-60c (control) is a single-stranded oligonucleotide which, unlike its double-stranded counterpart is not IFN-inducer [1].


Activity: CDS agonist

Formulation: naked or complexed with the transfection reagent LyoVec™

Control: HSV-60c single-stranded oligonucleotide


HSV-60 Naked:
- 200 µg lyophilized HSV-60 Naked
- 1.5 ml endotoxin-free water

- 100 µg lyophilized HSV-60/LyoVec
Note: Each vial contains 25 μg of HSV-60 complexed with 50 μg LyoVec™.
- 10 ml endotoxin-free water

Product is shipped at room temperature and should be stored at -20°C.


1. Unterholzner L. et al., 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11(11):997-1004.


Recent articles using InvivoGen HSV-60


HSV-60 Naked

Description CDS Agonist
Cat. Codetlrl-hsv60n
Unit Size200 µg
Price For price or distributor address,
please select your country


Description CDS Agonist - LyoVec™ complexed
Cat. Codetlrl-hsv60c
Unit Size100 µg
Price For price or distributor address,
please select your country
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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