ODN D-SL01 - TLR9 Agonist

Class B CpG oligonucleotide - Multispecies TLR9 ligand

ODN D-SL01 (double-stem loop ODN) is a synthetic oligonucleotide that contains unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs) that are recognized by TLR9 leading to strong immunostimulatory effects.

ODN D-SL01 is a type B CpG ODN and a TLR9 agonist in diverse vertebrate species, namely, humans, mice, rats, rabbits, pigs, and dogs.

ODN D-SL01 is composed of double stem loops, a phosphorothioate backbone, and two GACGTT motifs. D-SL01 has been shown to potently activate human B cells, NK cells, and mononuclear cells as well as PBMC/splenocytes obtained from diverse vertebrate species, namely, mice, rats, rabbits, dogs, and pigs [1].

ODN D-SL01 demonstrates anti-tumor activity in mice with established breast cancer [1].

Reference:

1. Yang L. et al., 2013. CpG oligodeoxynucleotides with double stem-loops show strong immunostimulatory activity. Int Immunopharmacol. 15(1):89-96.