ODN 2216

Class A CpG oligonucleotide - Human TLR9 ligand

CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in specific sequence contexts (CpG motifs). These CpG motifs are present at a 20-fold greater frequency in bacterial DNA than in mammalian DNA. CpG ODNs are recognized by Toll-like receptor 9 (TLR9), which leads to strong immunostimulatory effects.

ODN 2216 is a class A CpG ODN and is a ligand of choice for human TLR9. Class A CpG ODNs are characterized by a central, phosphodiester, CpG-containing palindromic motif and a 3’ phosphorothioate poly-G string.They induce high IFN-α production from plasmacytoid dendritic cells (pDCs) but are weak stimulators of TLR9-dependent NF-κB signaling.

ODN 2216TLR9 Agonist - Stimulatory CpG ODN, Class A, Human preferred 200 µg
1 mg
5 mg
Bulk quantity
ODN 2243 (ODN 2216 Control)Negative control for ODN 2216 200 µg
1 mg
5 mg
ODN 2216 BiotinTLR9 Agonist - Biotin-labelled CpG ODN 2216, class A, Human preferred2 x 50 µg
ODN 2216 FITCTLR9 Agonist - FITC-labelled CpG ODN 2216, Class A, Human preferred50 µg
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