Class A CpG oligonucleotide - Stimulatory mouse TLR9 ligand
ODN 1585 is a Class A CpG oligonucleotide (ODN), specifically designed for mouse Toll-like receptor 9 (TLR9). ODN 1585 has been optimized to indirectyl activate natural killer (NK) cells.
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in specific sequence contexts (CpG motifs). These CpG motifs are present at a 20-fold greater frequency in bacterial DNA than in mammalian DNA. CpG ODNs are recognized by Toll-like receptor 9 (TLR9), which leads to strong immunostimulatory effects. Class A CpG ODNs are characterized by a central, phosphodiester, CpG-containing palindromic motif and a 3’ phosphorothioate poly-G string.
The sequence of the ODN 1585 is ggGGTCAACGTTGAgggggg of 20 mer (the bases in capital letters are phosphodiester and those in lowercase are phosphorothioates).
Key features of InvivoGen's ODN 1585 products
- Potent activator of mouse TLR9
- Synthetic ODN with unmethylated CpG motifs
- Each lot is functionally tested
- Available in an in vitro standard or pre-clinical in vivo VacciGrade™
