Alhydrogel 2%
Vaccine Adjuvant: Aluminium hydroxide gel
Alhydrogel 2%, referred to as alum, is an aluminium hydroxide wet gel suspension. Alum induces a Th2 response by improving the attraction and uptake of antigen by antigen-presenting cells (APCs). It can also activate innate immunity pathways triggered by pattern recognition receptors (PRRs).
Alhydrogel 2% is VacciGrade™ (preclinical grade) for research use only, not for use in humans.
Specifications
Specificity: Th2 response
Working concentration: 1:9 - 1:1 (Alhydrogel:antigen)
CAS number: 21645-51-2
Aluminium content: 9.0 – 11.0 mg/ml
Appearance: White gelatinous precipitate
Documents
Contents
Alhydrogel 2% is provided as a ready-to-use, sterile wet gel suspension and is available in two quantities:
• 50 ml: cat. code # vac-alu-50
• 250 ml: cat. code # vac-alu-250
Alhydrogel 2% is shipped at room temperature and should be stored at room temperature. Product is stable for 6 months. DO NOT FREEZE.
Description
Alhydrogel 2% is an aluminium hydroxide (referred to as alum) wet gel suspension. Alum acts primarily through the formation of a depot at the injection site, enabling enhanced antigen availability, activation of antigen presenting cells (APCs) and uptake by immune cells [1]. It can also activate innate immunity pathways triggered by pattern recognition receptors (PRRs). The NLR pathway has been recently described as an important mechanism in alum adjuvancy [2]. Alum has been shown to activate the NLRP3 inflammasome although its role in alum-induced antibody response is controversial [3].
1. Morefield GL. et al., 2005. Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine 23(13): 1588-95.
2. Li H. et al., 2008. Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol. 181(1):17-21.
3. Franchi L. & Nuñez G., 2008. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur. J. Immunol. 38(8):2085-9
ORDERING
Alhydrogel 2%
| Description | Aluminium hydroxide gel |
|---|---|
| Cat. Code | vac-alu-50 |
| Unit Size | 50 ml |
| Price | For price or distributor address, please select your country |
Alhydrogel 2%
| Description | Aluminium hydroxide gel |
|---|---|
| Cat. Code | vac-alu-250 |
| Unit Size | 250 ml |
| Price | For price or distributor address, please select your country |
