AddaVax™
Vaccine Adjuvant: Squalene-Oil-in-water
AddaVax™ is a squalene-based oil-in-water nano-emulsion with a formulation similar to MF59® that has been licensed in Europe for adjuvanted flu vaccines [1].
Squalene is an oil more readily metabolized than the paraffin oil used in Freund’s adjuvants [1]. Squalene-based oil-in-water nano-emulsions promote a significant increase in antibody titers with reportedly more balanced Th1/Th2 responses than those obtained with alum [2]. This class of adjuvants is believed to act through recruitment and activation of APC and stimulation of cytokines and chemokines production by macrophages and granulocytes [1].
AddaVax™ is VacciGrade™ (preclinical grade) for research use only, not for use in humans.
The mark MF59® is a registered trademark of Novartis, and is used for comparative purposes only. AddaVax™ is not made by, affiliated with, sponsored by or endorsed by Novartis. Novartis has not evaluated or approved the representations contained herein.
Specifications
Specificity: Th2 response
Working concentration: 1:1 (addaVax:antigen)
Endotoxin level: <5 mg/ml (limit of detection)
Appearance: Off-white emulsion
Documents
Contents
AddaVax™ is provided as a ready-to-use sterile emulsion and is available in two quantities:
• 2 ml: cat. code # vac-adx-2
• 10 ml: cat. code # vac-adx-10
AddaVax™ is shipped at room temperature and should be stored at 4°C. AddaVax™ is stable for 6 months. DO NOT FREEZE.
Ref.
1. Ott G. et al., 2000. The adjuvant MF59: a 10-year perspective. Methods in Molecular Medicine, Vol 42, 211-228
2. Coffman RL et al., 2010. Vaccine adjuvants: putting innate immunity to work. Immunity, 33(4):492-503
ORDERING
AddaVax™
| Description | Squalene-oil-in-water |
|---|---|
| Cat. Code | vac-adx-2 |
| Unit Size | 2 ml |
| Price | For price or distributor address, please select your country |
AddaVax™
| Description | Squalene-oil-in-water |
|---|---|
| Cat. Code | vac-adx-10 |
| Unit Size | 10 ml |
| Price | For price or distributor address, please select your country |
