pDUO plasmid co-expressing TLR1 and TLR2 genes

pDUO-TLR1/TLR2 is an expression vector designed to co-express TLR1 and TLR2 genes known to interact with each other : human TLR1 (2358 bp) and  human TLR2 (2352 bp) or mouse TLR1 (2388 bp) and  mouse TLR2 (2355 bp).

The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

This gene is available in pDUO expression plasmid selectable with Blasticidin.


Human TLR1/TLR2 (pDUO-hTLR1/TLR2)

Mouse TLR1/TLR2 (pDUO-mTLR1/TLR2)


- 20 µg of lyophilized DNA
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)


TLR1, the first member of the Toll-Like Receptor family was identified by the presence of a domain homology found in both Drosophila Toll and human IL-1 receptors. So far, no direct ligands for TLR1 have been identified however it seems to act as a coreceptor. TLR1 has been shown to associate with TLR2 in response to triacylated lipopeptides [1], but not diacylated lipopeptides[2]. These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration.

1. Takeuchi O. et al., 2002. J Immunol, 169(1):10-14.
2. Takeuchi O. et al., 2001. Int Immunol, 13(7): 933-40.


pDUO backbone


Recent articles using InvivoGen pDUO-TLR1/TLR2



Description pDUO bearing human TLR1/TLR2 Gene
Cat. Codepduo-htlr1tlr2
Unit Size20 µg
Price For price or distributor address,
please select your country


Description pDUO bearing mouse TLR1/TLR2 Gene
Cat. Codepduo-mtlr1tlr2
Unit Size20 µg
Price For price or distributor address,
please select your country
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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