pDUO plasmid co-expressing TLR6 and TLR2 genes

pDUO-TLR6/TLR2 is an expression vector designed to co-express TLR6 and TLR2 genes known to interact with each other : human TLR6 (2388 bp) and human TLR2 (2352 bp) or murine TLR6 (2418 bp) and murine TLR2 (2352 bp).

The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

This gene is available in pDUO expression plasmid selectable with Blasticidin.


Human TLR6/TLR2 (pDUO-hTLR6/TLR2)

Mouse TLR6/TLR2 (pDUO-mTLR6/TLR2)


- 20 µg of lyophilized DNA
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)


TLR6 is expressed in spleen and BPL and, similarly to TLR1, acts as a co-receptor. Studies with dominant negative receptors have shown that TLR6 cooperates with TLR2 to recognize peptidoglycan and the yeast cell wall particle, zymosan [1].
Furthermore, TLR6- and TLR2-deficient mice were reported to be hyporesponsive to mycoplasma macrophage-activating lipopeptide-2 kD (MALP-2), a diacylated lipoprotein, suggesting that TLR2 and TLR6 coordinate the response to this ligand. By contrast, TLR2 is able to recognize bacterial lipoproteins triacylated at the N-terminus cysteine residue [2]. Thus TLR6 appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria.

1. Ozinsky A. et al. (2000). The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. PNAS 97(25):13766-71.
2. Takeuchi O. et al., 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol, 13(7): 933-40.


pDUO backbone



Description pDUO bearing human TLR6/TLR2 Gene
Cat. Codepduo-htlr6tlr2
Unit Size20 µg
Price For price or distributor address,
please select your country


Description pDUO bearing mouse TLR6/TLR2 Gene
Cat. Codepduo-mtlr6tlr2
Unit Size20 µg
Price For price or distributor address,
please select your country
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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