STING Ligands

Cyclic dinucleotides and xanthenone derivative

Cyclic dinucleotides (CDNs) and the xanthenone derivative DMXAA, were recently found to bind to and activate STING, leading to a potent type I IFN response.
Cyclic dinucleotidesCDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.

CDNs represent a promising new class of vaccine adjuvants. To assist your research needs, InvivoGen provides a large collection of CDNs available in two grades:
- InvivoGen Standard Grade: purity ≧ 95%, validated using cell-based assays;
- VacciGrade™: sterility guaranteed and endotoxin level < 1 EU/mg, in addition to the above-mentioned criteria.

Cyclic Dinucleotides

3'3'-cGAMP STING ligand 500 µg
1 mg
3'3'-cGAMP Control STING agonist negative control 1 mg
3’3’-cGAMP VacciGrade™ STING ligand - Cyclic [G(3’,5’)pA(3’,5’)p] 1 mg
3'3'-cGAMP Fluorinated NEW! STING ligand - Fluorinated cyclic diadenylate monophosphate 100 µg
2’3’-cGAMP STING ligand 500 µg
1 mg
5 mg
2'3'-cGAMP Control STING agonist negative control 1 mg
2’3’-cGAMP VacciGrade™ STING ligand - Cyclic [G(2’,5’)pA(3’,5’)p] 1 mg
2’3’-cGAM(PS)2 (Rp/Sp) STING ligand 250 µg
2’2’-cGAMP STING ligand 500 µg
1 mg
2’2’-cGAMP VacciGrade™ STING ligand - Cyclic [G(2’,5’)pA(2’,5’)p] 1 mg
c-di-AMP STING ligand 1 mg
c-di-AMP Control STING agonist negative control 1 mg
c-di-AMP VacciGrade™ STING ligand - Cyclic diadenylate monophosphate
Th1/Th2 response
1 mg
c-di-AMP Fluorinated NEW! STING ligand - Fluorinated cyclic diadenylate monophosphate 100 µg
2'3'-c-di-AMP NEW! STING ligand 500 µg
2’3’-c-di-AM(PS)2 (Rp,Rp) NEW! STING ligand - Bisphosphorothioate analog of c-di-AMP, Rp isomers 100 µg
500 µg
c-di-GMP STING ligand 1 mg
c-di-GMP Control STING agonist negative control 1 mg
c-di-GMP Fluorinated NEW! STING ligand 100 µg
c-di-GMP VacciGrade™ STING ligand - Cyclic diguanylate monophosphate
Th1/Th2 response
1 mg
c-di-IMP STING ligand 1 mg
c-di-UMP STING agonist negative control 1 mg

Xanthenone Analog

DMXAA Murine STING ligand - Xanthenone Analog 5 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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