Cyclic dinucleotides and xanthenone derivative
Cyclic dinucleotides (CDNs) and the xanthenone derivative DMXAA, were recently found to bind to and activate STING, leading to a potent type I IFN response.
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.
CDNs represent a promising new class of vaccine adjuvants. To assist your research needs, InvivoGen provides a large collection of CDNs available in two grades:
- InvivoGen Standard Grade: purity ≧ 95%, validated using cell-based assays;
- VacciGrade™: sterility guaranteed and endotoxin level < 1 EU/mg, in addition to the above-mentioned criteria.