STING Ligands

Cyclic dinucleotides and xanthenone derivative

Cyclic dinucleotides (CDNs) and the xanthenone derivative DMXAA, were recently found to bind to and activate STING, leading to a potent type I IFN response.
Cyclic dinucleotidesCDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.

CDNs represent a promising new class of vaccine adjuvants. To assist your research needs, InvivoGen provides a large collection of CDNs available in two grades:
- InvivoGen Standard Grade: purity ≧ 95%, validated using cell-based assays;
- VacciGrade™: sterility guaranteed and endotoxin level < 1 EU/mg, in addition to the above-mentioned criteria.

Cyclic Dinucleotides

2’2’-cGAMPSTING ligand 500 µg
1 mg
2’2’-cGAMP VacciGrade™STING ligand - Cyclic [G(2’,5’)pA(2’,5’)p]1 mg
2’3’-cGAMPSTING ligand 500 µg
1 mg
5 mg
2’3’-cGAMP VacciGrade™STING ligand - Cyclic [G(2’,5’)pA(3’,5’)p]1 mg
2'3'-cGAMP ControlSTING agonist negative control1 mg
2’3’-cGAM(PS)2 (Rp/Sp)STING ligand250 µg
3'3'-cGAMPSTING ligand 500 µg
1 mg
3’3’-cGAMP VacciGrade™STING ligand - Cyclic [G(3’,5’)pA(3’,5’)p]1 mg
3'3'-cGAMP ControlSTING agonist negative control1 mg
3'3'-cGAMP FluorinatedSTING ligand - Fluorinated cyclic diadenylate monophosphate100 µg
c-di-AMPSTING ligand1 mg
c-di-AMP VacciGrade™STING ligand - Cyclic diadenylate monophosphate
Th1/Th2 response
1 mg
c-di-AMP ControlSTING agonist negative control1 mg
c-di-AMP FluorinatedSTING ligand - Fluorinated cyclic diadenylate monophosphate100 µg
2'3'-c-di-AMPSTING ligand500 µg
2’3’-c-di-AM(PS)2 (Rp,Rp)STING ligand - Bisphosphorothioate analog of c-di-AMP, Rp isomers 100 µg
500 µg
2’3’-c-di-AM(PS)2 (Rp,Rp) VacciGrade™ NEWSTING ligand - Vaccine adjuvant500 µg
c-di-GMPSTING ligand1 mg
c-di-GMP ControlSTING agonist negative control1 mg
c-di-GMP FluorinatedSTING ligand100 µg
c-di-GMP VacciGrade™STING ligand - Cyclic diguanylate monophosphate
Th1/Th2 response
1 mg
2’3’-c-di-GMP NEWSTING ligand500 µg
c-di-IMPSTING ligand1 mg
c-di-UMPSTING agonist negative control1 mg

Xanthenone Analog

DMXAAMurine STING ligand - Xanthenone Analog5 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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