Antimicrobial Agent for Primary Cells

Primocin | InvivoGen

Primocin™ is an antibiotic formulation specifically designed to protect primary cell lines from cell culture contaminations. Primocin™ is active against both Gram+ and Gram- bacteria, mycoplasmas and fungi. Primocin™ is the first formulation to offer complete protection against microbial contaminants. There is no need to add Pen-Strep.

Primocin™ is non-toxic to primary cells. It acts on targets found only in micro-organisms. Bacterial targets are the DNA gyrase and the prokaryotic ribosomal subunits, 30S and 50S. The fungal target is ergosterol, a molecule only found in the cell membrane of fungi and yeasts.

Primocin has been used successfully in many primary cells, including mouse- and human-tumor derived cell lines [1], embryonic cells [2] and induced pluripotent stem cells [3-6].


Product concentration: 50 mg/ml

Recommended working concentration: 100 μg/ml

One ml Primocin™ is enough to treat 500 ml medium

Shipped at room temperature


Primocin™ is provided as a cell culture tested, sterile filtered light yellow solution at a concentration of 50 mg/ml in different formats:

- 10 x 1 ml vial (500 mg)

- 1 x 20 ml bottle (1 g)


1. Sanchez-Laorden B. et al., 2014. BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling. Sci Signal., 7(318)
2. Lionnet T. et al., 2011. A transgenic mouse for in vivo detection of endogenous labeled mRNA. Nat Methods., 8(2):165-70
3. Grabundzija I. et al., 2013. Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res., 41(3):1829-47
4. Tucker BA. et al., 2013. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. Elife, 2:e00824
5. Tucker BA. et al., 2013. Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med., 2(1):16-24
6. Zhou T. et al., 2012. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc. 7(12):2080-9.



Cat. Codeant-pm-1
Unit Size500 mg (10 x 1 ml)
Price For price or distributor address,
please select your country


Cat. Codeant-pm-2
Unit Size1 g (1 x 20 ml)
Price For price or distributor address,
please select your country
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