TLR3 Ligands

Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a molecular pattern associated with viral infection. Polyinosine-polycytidylic acid (poly(I:C)), a synthetic analog of dsRNA, is the ligand of choice for TLR3. Poly(I:C) is composed of a strand of poly(I) annealed to a strand of poly(C). The size of the strands varies. InvivoGen is the only company to provide poly(I:C) with two different sizes:
• Poly(I:C) (HMW) with a high molecular weight has an average size of 1.5-8 kb.
• Poly(I:C) (LMW) with a low molecular weight has an average size of 0.2-1 kb

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Fluorescently-labeled poly(I:C)-HMW is available. InvivoGen supplies polyadenylic–polyuridylic acid "poly(A:U)" a synthetic dsRNA that signals only through TLR3. HEK-Blue™ TLR3 Cells are used to validate the functionality of these ligands. Poly(I:C) VacciGrade™ (preclinical grade: sterile and endotoxin level

Poly(A:U) TLR3 Agonist - Polyadenylic-polyuridylic acid 10 mg
Poly(I:C) HMW TLR3 Agonist - Polyinosine-polycytidylic acid High molecular weight 10 mg
50 mg
Poly(I:C) (HMW) Biotin TLR3 Agonist - Biotin-labeled poly(I:C) (HMW) 10 µg
Poly(I:C) (HMW) Fluorescein TLR3 Agonist - Fluorescein-labeled poly(I:C) (HMW) 10 µg
Poly(I:C) (HMW) Rhodamine TLR3 Agonist - Rhodamine-labeled poly(I:C) (HMW) 10 µg
Poly(I:C) (HMW) VacciGrade™ TLR3 agonist - Polyinosine-polycytidylic acid
Th1 response
10 mg
Poly(I:C) LMW TLR3 Agonist - Polyinosine-polycytidylic acid Low molecular weight 25 mg
250 mg
Poly(I:C) (LMW) Rhodamine TLR3 Agonist - Rhodamine-labeled poly(I:C) (LMW) 10 µg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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