TLR4 Agonists

Toll-like receptor 4 (TLR4) is the receptor for Gram-negative lipopolysaccharide (LPS) and lipid A, its toxic moiety. InvivoGen supplies LPS from various bacteria and monophosphoryl lipid A (MPLA purified from S. minnesota R595 or synthetic MPLA from E. coli). MPLA VacciGrade™ (preclinical grade: guaranteed sterile) for use as a vaccine adjuvant is also available.

InvivoGen provides LPS with two grades of purity:
- Standard LPS: LPS-EB and LPS-EK are standard preparations of lipopolysaccharide. They are extracted by a phenol-water mixture. LPS-EB and LPS-EK contain other bacterial components, such as lipopeptides, and therefore stimulate both TLR4 and TLR2.

- Ultra-pure LPS:  Ultrapure LPS-EB (E. coli 0111:B4), LPS-EK (E. coli K12) and LPS-SM (S. minnesota Re type) are extracted by successive enzymatic hydrolysis steps and purified by the phenol-TEA-DOC extraction protocol.

The functionality of these TLR ligands are validated using HEK-Blue™ TLR4 Cells.


LPS-B5 (LPS from E. coli 055:B5)TLR4 Agonist - Lipopolysaccharide from E. coli 055:B5 Standard (5 mg)
Ultrapure (5 mg)
LPS-EB (LPS from E. coli O111:B4)TLR4 Agonist - Lipopolysaccharide from E. coli 0111:B4 Standard (5 mg)
Ultrapure (5 x 10e6 EU)
LPS-EB BiotinTLR4 Agonist - Biotinylated ultrapure LPS from E. coli 0111:B4500 µg
LPS-EB VacciGrade™Lipopolysaccharide from E. coli 0111:B4 strain - TLR4-based adjuvant5 x 10e6 EU
LPS-EK (LPS from E. coli K12)TLR4 Agonist - Lipopolysaccharide from E. coli K12 Standard (5 mg)
Ultrapure (1 mg)
LPS-PG (LPS from P. gingivalis)TLR2/TLR4 or TLR4 Agonist - LPS from P. gingivalis Standard (1 mg)
Ultrapure (1 mg)
LPS-SM (LPS from S. minnesota R595)TLR4 Agonist - Ultrapure lipopolysaccharide from Salmonella minnesota R5955 mg

Monophosphoryl Lipid A

MPLA-SMTLR4 Agonist - Monophosphoryl lipid A from Salmonella minnesota R5951 mg
MPLA SyntheticTLR4 Agonist - Synthetic monophosphoryl lipid A1 mg
MPLA-SM VacciGrade™TLR4 agonist - Monophosphoryl lipid A
Th1 response
1 mg
MPLA Synthetic VacciGrade™TLR4 agonist - Synthetic monophosphoryl lipid A
Th1 response
1 mg

Heat-killed Bacteria

HKSTTLR2 / TLR4 Agonist - Heat Killed Salmonella typhimurium10e10 cells
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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