STING Products

STING pathwaySTING (stimulator of interferon genes), alternatively known as MPYS, TMEM173, MITA and ERIS, is a key sensor of cytosolic nucleic acids. 
STING, initially thought to serve solely as an adaptor protein for mediating signaling by cytosolic DNA sensors (CDS), was recently found to be a direct sensor of cyclic dinucleotides (CDNs).

More info on STING

Interestingly, a variety of natural variants of human STING (hSTING) have been identified. The presence of nonsynonymous variants of hSTING, some in high frequencies is indicative of its implicit role in disease. It is important to be aware that variant hSTING alleles differentially respond to cGAMPs.

InvivoGen offers a set of tools to study STING signaling pathway: Cyclic dinucleotides, recently found to bind to and activate STING, STING Reporter cells and STING variants, cloned and fully-sequenced into an expression plasmid.

STING Products

STING LigandsCyclic Dinucleotides
STING VariantsSTING variants open-reading frames on expression vectors
STING Reporter CellsStable human or murine KO or KD STING reporter cells
Recombinant human STINGNEWCHO expressed human STING (R232) protein
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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