Antibody Isotype Families

Clinically relevant antibodies in various Ig isotypes

Monoclonal antibodies (mAbs) have become a major tool in cancer therapy. They function through various mechanisms with the ultimate effect of priming either the innate or adaptive arm of the immune system to target tumor cells for destruction. The efficacy of antibodies is governed by their bifunctional nature: the variable region confers antigen specificiy and the constant region triggers antibody-mediated effector functions by engaging a variety of Fc receptors. These effector functions include complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). One approach employed to enhance the efficacy of therapeutic antibodies is to modify the immunoglobulin (Ig) constant region.

Effector functions Native human isotypes Engineered human isotypes Native mouse isotypes
IgG1 IgG2 IgG3 IgG4 IgM IgA1 IgA2 IgE IgG1NQ IgG1fut IgG4S228P   IgG1     IgG2a     IgA  
ADCC ++ +/- ++ +/- + + + + - ++++ +/- +/- ++ +
ADCP +++ +/- ++ + - + + - - +++ + + +++ +
CDC ++ + +++ - +++ - - - +/- + - - ++ -

More info

InvivoGen provides a series of clinically relevant antibodies, such as anti-hCD20 (rituximab), anti-HER2 (trastuzumab) and anti-hPD1 (nivolumab), available in their original format or with different Ig isotypes, either native or engineered, thus constituting an antibody isotype family (3 different isotypes) or collection (up to 14 different isotypes). These antibody isotype families or collections will help you study the effector functions between different isotypes and determine which isotype is the most suitable for your application.

InvivoGen’s clinically relevant antibodies are generated by recombinant DNA technology, produced in CHO cells and purified by affinity chromatography. They are validated by flow cytometry, are sterile and contain no sodium azide. All of these antibodies feature the human (or murine) kappa light chain.

Larger quantities are available upon request.

Antibody Isotype Families

Anti-hCD20 isotype collectionCollection of antibodies, variable region of rituximab (anti-CD20)
Anti-hCTLA4 isotype familyFamily of antibodies, variable region of ipilimumab (anti-hCTLA4)
Anti-hEGFR isotype familyFamily of antibodies, variable region of cetuximab (anti-hEGFR)
Anti-HER2 isotype familyFamily of antibodies, variable region of trastuzumab (anti-HER2)
Anti-hPD1 isotype familyFamily of antibodies, variable region of nivolumab (anti-PD1)
Anti-hPD-L1 isotype familyNEWFamily of antibodies, variable region of atezolizumab (anti-PD-L1)
Anti-hTNF-α isotype collectionFamily of antibodies, variable region of adalimumab (anti-hTNF-α)
Anti-hVEGF isotype familyFamily of antibodies, variable region of bevacizumab (anti-hVEGF)
Anti-β-Gal isotype familyAntibody isotype family targeting beta-galactosidase - Isotype controls
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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