Anti-TLR2 Antibodies

InvivoGen provides a collection of monoclonal and polyclonal antibodies targeting human and murine Toll-like receptor 2 (TLR2) for neutralization and detection. TLR2 is involved in the recognition of a wide array of microbial molecules. TLR2 recognizes peptidoglycan, lipoteichoic acid and lipoprotein from gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast cell wall. TLR2 cooperates with TLR6 in response to diacylated mycoplasmal lipopeptide [1], and associates with TLR1 to recognize triacylated lipopetides [2,3]. Simultaneous expression of the extracellular and intracellular domains of both TLR1 and TLR2 is essential for ligand recognition and subsequent ligand-induced signal activation [4]. Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14 [5].

1. Girard R. et al., 2003. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci. 116:293-302.
2. Ozinsky A. et al., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA. 97:13766-71.
3. Thakran S. et al., 2008. Identification of Francisella tularensis lipoproteins that stimulate the Toll-like receptor (TLR) 2/TLR1 heterodimer. J Biol Chem 283: 3751-9.
4. Sandor F. et al., 2003. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkB signaling. J Cell Biol. 162: 1099-10.
5. Lotz S. et al., 2004. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 75(3):467-77.

Anti-hTLR2-IgAHuman TLR2 Detection and Neutralizing antibody - Monoclonal Human IgA2 (B4H2)100 µg
Anti-mTLR2-IgGMouse TLR2 Neutralizing antibody - Monoclonal Mouse IgG2a (C9A12)100 µg
MAb-hTLR2Human TLR2 Detection antibody - Monoclonal Mouse IgG2a (TL2.1)100 µg
MAb-mTLR2Mouse TLR2 Detection and Neutralizing antibody - Monoclonal Mouse IgG1 (T2.5)100 µg
PAb-hTLR2Human TLR2 Neutralizing antibody - Polyclonal Rat IgG200 µg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "".