Anti-hCD20 isotype collection

The Anti-hCD20 isotype collection features the variable region of rituximab. Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes. Binding of rituximab to CD20 results in cell destruction through different mechanisms including direct signaling of apoptosis, complement activation and cell-mediated cytotoxicity.
Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukaemia.

The anti-hCD20 isotype collections has been generated by recombinant DNA technology. It has been produced in CHO cells and purified by different types of affinity chromatography: protein G for IgG isotypes, protein L for IgE and IgM, and peptide M for the human IgA isotypes.

Human antibodies

Anti-hCD20-hIgG1Human CD20 (rituximab) antibody - Human IgG1100 µg
Anti-hCD20-hIgG1futNon-fucosylated Human CD20 (rituximab) antibody - Human IgG1100 µg
Anti-hCD20-hIgG1NQNon-glycosylated Human CD20 (rituximab) antibody - Human IgG1100 µg
Anti-hCD20-hIgG2Human CD20 (rituximab) antibody - Human IgG2100 µg
Anti-hCD20-hIgG3Human CD20 (rituximab) antibody - Human IgG3100 µg
Anti-hCD20-hIgG4Human CD20 (rituximab) antibody - Human IgG4100 µg
Anti-hCD20-hIgG4 (S228P)Engineered Human CD20 (rituximab) antibody - Human IgG4100 µg
Anti-hCD20-hIgMHuman CD20 (rituximab) antibody - Human IgM100 µg
Anti-hCD20-hIgA1Human CD20 (rituximab) antibody - Human IgA1100 µg
Anti-hCD20-hIgA2Human CD20 (rituximab) antibody - Human IgA2100 µg
Anti-hCD20-hIgEHuman CD20 (rituximab) antibody - Human IgE100 µg

Murine antibodies

Anti-hCD20-mIgG1Human CD20 (rituximab) antibody - Murine IgG1100 µg
Anti-hCD20-mIgG2aHuman CD20 (rituximab) antibody - Murine IgG2a100 µg
Anti-hCD20-mIgAHuman CD20 (rituximab) antibody - Murine IgA100 µg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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