RLR Ligands

The RIG-I-Like receptors (RLRs), RIG-I and MDA-5, detect viral RNA species and signal through the adaptator molecule IPS-1 inducing an antiviral response by triggering a type-I interferon response (IFN-α and IFN-β).

InvivoGen provides two types of RLR ligands:
• 5'ppp dsRNA, a specific agonist of RIG-I
• Poly(I:C)/LyoVec complexes that are recognized by RIG-I and/or MDA-5 depending of the size of poly(I:C)

The activity of all RLR ligands is tested using RLR reporter cell lines.

RLR Ligands Products

5′ppp-dsRNA RIG-I Agonist 25 µg
100 µg
5′ppp-dsRNA Control Negative control for 5′ppp-dsRNA 25 µg
100 µg
Poly(dA:dT) Naked RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer 200 µg
1 mg
Poly(dA:dT)/Lyovec™ RIG-I Agonist - CDS Agonist - AIM2 Inflammasome Inducer 100 µg
Poly(dG:dC) Naked RIG-I Agonist - CDS Agonist 200 µg
Poly(dG:dC)/Lyovec™ RIG-I Agonist - CDS Agonist 100 µg
Poly(I:C) (HMW) / LyoVec™ RIG-I/MDA-5 Agonists 100 µg
Poly(I:C) (LMW) / LyoVec™ RIG-I/MDA-5 Agonists 100 µg
Poly(I:C) HMW TLR3 Agonist - Polyinosine-polycytidylic acid High molecular weight 10 mg
50 mg
Poly(I:C) LMW TLR3 Agonist - Polyinosine-polycytidylic acid Low molecular weight 25 mg
250 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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