The RIG-I-Like receptors (RLRs), RIG-I and MDA-5, detect viral RNA species and signal through the adaptator molecule IPS-1 inducing an antiviral response by triggering a type-I interferon response (IFN-α and IFN-β).
InvivoGen provides two types of RLR ligands:
• 5'ppp dsRNA, a specific agonist of RIG-I
• Poly(I:C)/LyoVec complexes that are recognized by RIG-I and/or MDA-5 depending of the size of poly(I:C)
The activity of all RLR ligands is tested using RLR reporter cell lines.