Cytosolic dsDNA Sensors - CDSs
Double-stranded DNA (dsDNA) is a potent inducer of type I interferons. Several sensors of cytosolic dsDNA have been identified, including DAI, RIG-I and LRRFIP1, which trigger different signaling pathways in a cell-type specific manner. These sensors recognize AT-rich B-form dsDNA and GC-rich Z-form dsDNA.
Recently, AIM2 has been identified as another cytosolic DNA sensor upon activation it forms an inflammasome leading to the secretion of IL-1β.
More info on cytosolic dsDNA sensors
InvivoGen provides a growing list of tools to study the cytosolic dsDNA sensors (CDSs). These tools include CDS reporter cells, synthetic analogs of dsDNA as CDS ligands, different molecules that act as CDS inhibitors, and a collection of human and mouse CDS and related genes.
