Opportunities at InvivoGen

Chimiste organicien (H/F)

Wednesday 11 January, 2017
Location : Toulouse, France

InvivoGen recrute un(e) technicien(ne) en chimie organique expérimenté(e).

Missions principales

La personne aura en charge la synthèse et le développement de nouvelles molécules dans des projets en « drug discovery » au sein d’un environnement multidisciplinaire dynamique.

Profil

Chimiste en synthèse organique titulaire d’un diplôme BAC+2/+3 (BTS, DUT, Licence Pro.). Les candidats retenus justifieront d’une bonne maîtrise des principales techniques de synthèse organique multi-étapes et d’une bonne connaissance des principales techniques de purification et d´analyse structurale (chromatographie, HPLC, RMN).
Une expérience de recherche à l’interface chimie-biologie serait également très appréciée. 

Qualités requises

Le poste proposé requiert des qualités de rigueur, d’organisation et d’efficacité.
La personne sera dotée d'un réel sens du relationnel pour évoluer à l’interface de différents services au sein de la société. 

Si vous êtes intéressés, veuillez envoyer votre CV accompagné d'un résumé (utilisant ChemDraw ou un programme équivalent) soulignant quelques exemples significatifs de votre expérience en synthèse organique. Précisez également vos disponibilités ainsi que les noms et coordonnées de 2 références.

Poste

Poste en CDD d’une durée de 12 mois. Date entrée en fonction : 01/03/2017.

Merci d'envoyer vos CV et lettre de motivation par email à p1702@invivogen.fr.

 

Senior Scientist, Drug Formulation

Friday 05 August, 2016
Location : Toulouse, France

About the position:

InvivoGen Therapeutics is presently seeking a highly motivated and talented scientist for a senior position in drug formulation. Working in tight collaboration with the President, the Head of Biology and the Head of Medicinal Chemistry, the Senior Scientist will be responsible for proposing, developing and evaluating diverse formulations of the company’s small-molecule and biologic candidates for preclinical and early clinical development. The position will entail long-term planning and daily execution of the following tasks:

  • Formulation of immunomodulatory organic molecules (in solution or lyophilized) for preclinical or early clinical studies;
  • Biological and physicochemical characterization of new formulations;
  • Strategic formulation based on desired therapeutic administration route in preclinical or early clinical studies (IP, IV, transdermal, intranasal, etc.);
  • Method development for the preparation, lyophilization, re-suspension, analytical characterization and scale-up of new formulations;
  • Designing, performing and monitoring in vitro and in vivo studies to characterize new formulations in preclinical or early clinical studies;
  • Adapting existing pharmacologic formulations to incorporate new components;
  • Proposing and assessing various drug-delivery vehicles such as liposomes, dendrimers, cell-penetrating peptides, microparticles and nanoparticles, microcapsules and nanocapsules, etc.
  • Liaising with CROs for out-sourcing of formulation tasks (safety studies, pilot-scale GMP synthesis, animal PD/PK studies, etc.); 
  • Daily collaboration with the Company’s chemists and biologists;
  • Close collaboration with the Company’s QA & Regulatory Affairs manager for all regulatory affairs issues (ANSM, EMA, FDA, etc.);
  • Keeping abreast of new developments in drug formulation (industry activity, clinical trials, patents and scientific literature);
  • Periodic contributions to scientific publications and/or presentations (patents, articles, conference posters, etc.).

About the candidate:

The ideal candidate will have at least 10 years of biotech/pharma industry experience in drug formulation; possess a solid understanding of the drug-development process, including in vivo preclinical studies; and have worked on formulation in drug development programs from early preclinical research into early clinical development

Essential: 

  • A PhD in Chemistry, Biochemistry or Pharmacology;
  • At least 10 years of industry experience in drug development;
  • Have worked on formulation of at least two drug candidates from early discovery up through Phase I or later;
  • A solid list of authored scientific publications and presentations, including patents, while in industry; 
  • Flexibility to adapt to the dynamic environment of a small drug-development company;
  • Fluency in written and spoken English;
  • Strong interpersonal, presentation and writing skills;
  • Independent but also a team player.

Desired:

  • Fluency in French;
  • Expertise in transfection of nucleic acids and/or delivery of immunomodulatory compounds.
  • Experience working with small organic molecules as well as biologics.

 

Location: Toulouse, France 

Salary: Commensurate with candidate’s experience

 

About InvivoGen Therapeutics:

InvivoGen Therapeutics is a rapidly expanding subsidiary of InvivoGen that seeks to leverage the Parent Company’s expertise in innate immune biology to develop novel treatments from discovery up to the early clinical stage. The Company recently completed a Phase I trial in gene therapy for pancreatic cancer, which it will follow up with a Phase II trial in mid-2016, and is planning a separate Phase I trial in immuno-oncology for pancreatic cancer in the same year. Both InvivoGen Therapeutics and its parent company, InvivoGen, are privately held and are based in San Diego (USA) & Toulouse (France).

Please send your application and CV by email to p1607@invivogen.fr.

 

Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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